Glucosum-6-phosphas dehydrogenas (G6PDH)

Cas No. : 9001-40-5

EC No.: 1.1.1.49

Sarcina: 5ku, 100ku, 500ku,1000KU.

depictio producti

Descriptio

Glucosum 6 phosphas dehydrogenas (G6PD) defectus est conditio hereditaria in qua cellae rubrae sanguineae (hemolysis) destruuntur cum corpus quibusdam escis, medicamentis, infectionibus vel accentus obnoxium est.Incidit cum homo deficiens vel humilis gradus enzyme glucose-6-phosphatae dehydrogenas habet.Hoc enzyme adiuvat rubrum sanguinem cellulis bene operantibus.Symptomata per episodium hemolyticum includere possunt urinam obscuram, lassitudinem, pallorem, ratem cordis rapidam, suspirium brevitatem, cutis flaventia (ictema regio).Defectus G6PD hereditario modo recessivo X coniuncto et symptomata magis in maribus (praesertim Africanis et Americanis e partibus quibusdam Africae, Asiae et Mediterranei).Causatur ex mutationibus geneticis in gene G6PD.

Dehydrogenas glucosa-6-phophate (G-6-PDH) constat e duobus subunitis ponderis molecularis aequivalentis. Amino acidum monomeris consecutio divulgata est. G-6-PDH adhibitus est in pertentatione ad nicotinamideum adeninum dinucleotidem et texti pyridinem nucleotides.G-6-PDH reduci potest ex solutionibus urea-denaturae.

Glucosum 6-phosphatum dehydrogenas regulatorium enzyme clavis est in primo gressu phosphatis pentosi viae.G-6-P-DH oxidizes glucoses-6- phosphas coram NADP⁺6- phosphogluconate cedere.Polyacrylamides gel electrophoresis, actio inficiens, et anti-fermentatum G-6- PDH, anticorpus studia immuna, G-6-PDH glycoprotein esse significarunt.

Chemical Structure

Principium reactionem

D-Glucosum-6-phosphas + NAD⁺→D-Glucono-δ-lactone-6-phosphas + NADH+H⁺

Specification

Test Items	Specifications
Descriptio	Pulvis albus amorpho, lyophilized
Actio	≥150U/mg
Puritas (SDS-PAGE)	≥90%
Solubilitas (10mg pulveris / ml)	Patet
NADH/NADPH oxydatus	≤0.1%
Glutathione reductase	≤0.001%
Phosphoglucose isomerase	≤0.001%
Creatine phosphokinase	≤0.001%
6-Phosphogluconata dehydrogenase	≤0.01%
Myokinase	≤0.01%
Hexokinase	≤0.001%